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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Triptolide, Doxorubicin
Phytochemical Name Triptolide (PubChem CID: 107985 )
Anticancer drug Name Doxorubicin (PubChem CID: 31703 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 154
Ref_1
Pair Name Triptolide, Doxorubicin
Disease Info [ICD-11: 2B33.4] Leukemia Investigative
Biological Phenomena Induction-->Ferroptosis
Gene Regulation Down-regulation Expression GPX4 hsa2879
Down-regulation Expression NFE2L2 hsa4780
In Vitro Model K-562 Blast phase chronic myelogenous leukemia Homo sapiens (Human) CVCL_0004
HL-60 Adult acute myeloid leukemia Homo sapiens (Human) CVCL_0002
Result The present study indicated that Nrf2 served a critical role in leukemia cell resistance to DOX and triptolide‑induced ferroptosis and suggested a potential strategy of combination therapy using triptolide and DOX in leukemia treatment.
03. Reference
No. Title Href
1 Triptolide promotes ferroptosis by suppressing Nrf2 to overcome leukemia cell resistance to doxorubicin. Mol Med Rep. 2023 Jan;27(1):17. doi: 10.3892/mmr.2022.12904. Click
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